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High levels of cannabinoid quinones in commercial vaping products and additional accumulation following vaping is significant as quinones can exert toxicity through multiple mechanisms, primarily modification of proteins or other biological molecules and redox cycling

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Concurrently, GSHa critical intracellular antioxidantbecomes depleted, compromising the cell's capacity to neutralize ROS and lipid peroxidation products, thereby accelerating ferroptotic progression (21)

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Ethics statement The research protocol was approved by the hospital ethics committee (Ethics review document: 2020001), and all the research subjects signed informed consent form